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Article

Identification of the role of presenilins beyond Alzheimer's disease.

Pharmacological research - 1 Oct 2004

Thinakaran Gopal, Parent Angèle T

Abstract excerpt

Mutations in the genes encoding presenilin 1 (PS1) and presenilin 2 (PS2) account for the majority of the cases of familial early-onset Alzheimer's disease (FAD). Presenilins (PSs) facilitate the intramembraneous cleavage of amyloid precursor protein (APP), coined gamma-secretase cleavage, which generates beta-amyloid peptides (A beta). Considerable evidence suggests that FAD-linked PS variants exert their...

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Source

Identifiers

PMID: 15304238
DOI: 10.1016/j.phrs.2003.12.026

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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