Article

Divergent consequences of PSEN1 knockout and PSEN2 knockout in stem cell derived models of the brain

2026-04-13

Abstract excerpt

γ-secretase is a multi-subunit enzyme complex responsible for cleaving hundreds of substrates in diverse cellular contexts. Variation in subunit composition - including the use of alternate catalytic subunits Presenilin 1 (PSEN1) and Presenilin 2 (PSEN2) - results in diverse γ-secretase complexes. Point mutations in PSEN1 and PSEN2 cause familial forms of Alzheimer’s disease, while loss-of-function mutations in...

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Literature Corpus work: deb4c428-69b2-584d-9ddc-72c75b263a11
DOI: 10.64898/2026.04.09.717238

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