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Article

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues

1 Dec 1996

Abstract excerpt

Mutations in genes encoding related proteins, termed presenilin 1 (PS1) and presenilin 2 (PS2), are linked to the majority of cases with early-onset familial Alzheimer's disease (FAD). To clarify potential function(s) of presenilins and relationships of presenilin expression to pathogenesis of AD, we examined the expression of PS1 and PS2 mRNA and PS1 protein in human and mouse. Semi-quantitative PCR of...

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PMID: 8922407
DOI: 10.1523/jneurosci.16-23-07513.1996

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