Article
The physiological role of presenilins in cellular differentiation: lessons from model organisms.
European archives of psychiatry and clinical neuroscience - 1 Jan 1999
Baumeister R
Abstract excerpt
Mutations in the human presenilin genes cause the most frequent and aggressive forms of Alzheimer's Disease. They results in an increase of the 42 amino acid variant of amyloid beta peptide that rapidly aggregates into neurotoxic plaques. In addition, lack of presenilin activity prevents the prot...
Topics
- Alzheimer Disease
- Animals
- Caenorhabditis elegans
- Cell Differentiation
- Disease Models, Animal
- Gene Expression Regulation, Developmental
- Humans
- Membrane Proteins
- Mice
- Mutation
- Presenilin-1
- Presenilin-2