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Article

The physiological role of presenilins in cellular differentiation: lessons from model organisms.

European archives of psychiatry and clinical neuroscience - 1 Jan 1999

Baumeister R

Abstract excerpt

Mutations in the human presenilin genes cause the most frequent and aggressive forms of Alzheimer's Disease. They results in an increase of the 42 amino acid variant of amyloid beta peptide that rapidly aggregates into neurotoxic plaques. In addition, lack of presenilin activity prevents the proteolytic cleavage of the Notch receptor of intercellular signaling. The biological role of presenilins is evolutionary...

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Identifiers

PMID: 10653283
DOI: 10.1007/s004060050100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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