Article

Quantitative Comparison of Presenilin Protein Expression Reveals Greater Activity of PS2-γ-Secretase

2023-05-10

Abstract excerpt

γ-Secretase processing of APP has long been of interest in the pathological progression of Alzheimer’s disease (AD) due to its role in the generation of amyloid-β. The catalytic component of the enzyme are the presenilins of which there are two homologues, Presenilin-1 (PS1) and Presenilin-2 (PS2). The field has focussed on the PS1 form of this enzyme, as it is typically considered the more active at APP processin...

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Literature Corpus work: e63b1b4a-5a85-5300-b20c-90df26f2f0be
DOI: 10.1101/2023.05.09.540102

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