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fRagmentomics: an R package for integrating cell-free DNA fragment features with mutational status to support liquid biopsy interpretation.

Bioinformatics (Oxford, England) - 7 Apr 2026

Maudet Killian, Samaniego Juliette, Pradat Yoann, Bernard Elsa

Abstract excerpt

SUMMARY: Liquid biopsy offers a non-invasive approach to study tumor-derived genetic material circulating in plasma. Beyond genetic alterations, the fragmentomic features of cell-free DNA-such as fragment size, genomic position, and end-motifs-provide valuable insights into the biological and clinical context of DNA release. fRagmentomics is a user-friendly R package designed to characterize cfDNA fragments...

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Identifiers

PMID: 41886314
DOI: 10.1093/bioinformatics/btag152
PMCID: PMC13070676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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