Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis of aberrant position and sequence of plasma DNA fragment ends in patients with cancer

11 Jan 2023

Abstract excerpt

Genome-wide fragmentation patterns in cell-free DNA (cfDNA) in plasma are strongly influenced by cellular origin due to variation in chromatin accessibility across cell types. Such differences between healthy and cancer cells provide the opportunity for development of novel cancer diagnostics. Here, we investigated whether analysis of cfDNA fragment end positions and their surrounding DNA sequences reveals the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related molecular mechanisms research
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36630480
DOI: 10.1126/scitranslmed.abm6863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of aberrant position and sequence of plasma DNA fragment ends in patients with cancerPMID 36630480Read ↗

Analysis of fragment ends in plasma DNA from patients with cancerSemantic proximity Read ↗

Cell-free DNA end characteristics enable accurate and sensitive cancer diagnosisSemantic proximity Read ↗

Cancer-like fragmentomic characteristics of somatic variants in cell-free DNASemantic proximity Read ↗

Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patternsSemantic proximity Read ↗

Multi-modal cell-free DNA genomic and fragmentomic patterns enhance cancer survival and recurrence analysisSemantic proximity Read ↗

Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regionsSemantic proximity Read ↗

Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients.Semantic proximity Read ↗

fRagmentomics: an R package for integrating cell-free DNA fragment features with mutational status to support liquid biopsy interpretation.Semantic proximity Read ↗

Comprehensive Analysis of Cell-Free DNA Fragmentation Across Cancer StagesSemantic proximity Read ↗

Combining mutation detection with fragmentomics features leads to improved tumor-informed ctDNA detectionSemantic proximity Read ↗

Cell-free DNA Fragmentation Profiling at Transcription Start Sites Improves upon Cancer-Type-Specific Region Selection for Cancer DetectionSemantic proximity Read ↗

CRAG: <i>De novo</i> characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.