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Genome-wide cell-free DNA fragmentation in patients with cancer

29 May 2019

Abstract excerpt

. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patients with cancer had altered fragmentation profiles. We used this method to analyse the...

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PMID: 31142840
DOI: 10.1038/s41586-019-1272-6

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