Article

Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats

2023-07-19

Abstract excerpt

Precision-cut liver slices (PCLS) are increasingly used as a model to investigate anti-fibrotic therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic stimuli in culture, which reflects only the early stages of fibrosis. The performance of PCLS from cirrhotic animals has not been well characterized and there is no consensus on optimal culture conditions. In this study, we report a...

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Literature Corpus work: 8da3d32f-83ca-5ed9-9e8e-bccdcd0727c3
DOI: 10.1101/2023.07.18.549535

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