Article

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

2021-07-26

Abstract excerpt

Non-alcoholic steatohepatitis (NASH) is a progressive and severe liver disease, characterized by lipid accumulation, inflammation, and downstream fibrosis. Despite its increasing prevalence, there is no approved treatment yet available for patients. This has been at least partially due to the lack of predictive preclinical models for studying this complex disease. Here, we present a 3D in vitro microtissue model t...

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Literature Corpus work: e46048d5-4df3-5e2c-9469-73cc9406aa41
DOI: 10.21203/rs.3.rs-737717/v1

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