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Article

Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices

21 Nov 2019

Abstract excerpt

Our knowledge of complex pathological mechanisms underlying organ fibrosis is predominantly derived from animal studies. However, relevance of animal models for human disease is limited; therefore, an ex vivo model of human precision-cut tissue slices (PCTS) might become an indispensable tool in fibrosis research and drug development by bridging the animal-human translational gap. This study, presented as two...

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PMID: 31754732
DOI: 10.1007/s00204-019-02611-6

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