Precision-Cut Liver Slices as an <i>ex vivo</i> model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis

Abstract excerpt

<h4>Background</h4> Precision-Cut Liver Slices (PCLS) are an ex vivo culture model developed to study hepatic drug metabolism. One of the main benefits of this model is that it retains the structure and cellular composition of the native liver. PCLS also represents a potential model system to study liver fibrosis in a setting that more closely approximates in vivo pathology than in vitro methods. The aim of th...

Topics

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• Angiogenesis Inhibitors
• Angiotensin-Converting Enzyme Inhibitors
• Drug-Induced Hepatotoxicity and Protection
• Drug Transport and Resistance Mechanisms
• Liver Cirrhosis
• Liver Disease Diagnosis and Treatment
• Liver physiology and pathology
• Organ Transplantation Techniques and Outcomes

Identifiers and source

Literature Corpus work

224636fb-bca9-5eab-970c-48a1ff3e323d

DOI

10.1101/2023.10.30.564772