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Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats

3 Jul 2024

Abstract excerpt

Precision-cut liver slices (PCLS) are increasingly used as a model to investigate anti-fibrotic therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic stimuli in culture, which reflects only the early stages of fibrosis. The effects of different culture conditions on PCLS from cirrhotic animals has not been well characterized and there is no consensus on optimal methods. In this...

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PMID: 38961190
DOI: 10.1038/s41598-024-66235-2

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