Article

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices

2018-05-25

Abstract excerpt

<h4>Summary box</h4> What is already known about this subject? Currently there are no effective anti-fibrotic drugs to treat liver fibrosis and there is an urgent unmet need to increase our knowledge of the disease process and develop better tools for anti-fibrotic drug discovery. Preclinical in vitro cell cultures and animal models are widely used to study liver fibrosis and test anti-fibrotic drugs, but have s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9bc7ed9-43a7-57b4-a2ac-64cec387af04
DOI: 10.1101/331173

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slicesDOI 10.1101/331173Read

Best Practices and Progress in Precision-Cut Liver Slice CulturesSemantic proximity Read

Precision-Cut Liver Slices as an <i>ex vivo</i> model to evaluate antifibrotic therapies for liver fibrosis and cirrhosisSemantic proximity Read

A MICROFLUIDIC DEVICE FOR LONG-TERM MAINTENANCE OF ORGANOTYPIC LIVER CULTURESSemantic proximity Read

Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic ratsSemantic proximity Read

Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic ratsSemantic proximity Read

Scalable production of tissue-like vascularised liver organoids from human PSCsSemantic proximity Read

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic OrganoidsSemantic proximity Read

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional ModelsSemantic proximity Read

Generation of liver organoids from human induced pluripotent stem cells as liver fibrosis and steatosis modelsSemantic proximity Read

Ex vivo precision-cut liver slices model disease phenotype and monitor therapeutic response for liver monogenic diseasesSemantic proximity Read

Scalable production of tissue-like vascularized liver organoids from human PSCsSemantic proximity Read

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional ModelsSemantic proximity Read