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Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene

2020-04-18

Abstract excerpt

Genome-wide association studies (GWAS) of systemic lupus erythematosus (SLE) explain only ∼15% of genetic risk, indicating genes of modest effect remain to be discovered. Association clustering methods such as OASIS are more apt at identifying modest genetic effects. 410 genes were mapped to previously identified OASIS GWAS SLE loci and investigated for expression in SLE GEO datasets. GSE50395 dataset from Cordoba...

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Literature Corpus work
8d88f096-1a60-5e52-9018-3ec6e5f8350a
DOI
10.1101/2020.04.17.047332
Open publication

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Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus geneDOI 10.1101/2020.04.17.047332
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