Article
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.
American journal of human genetics - 7 Jan 2011
Lessard Christopher J, Adrianto Indra, Kelly Jennifer A, Kaufman Kenneth M, Grundahl Kiely M, Adler Adam, Williams Adrienne H, Gallant Caroline J, Anaya Juan-Manuel, Bae Sang-Cheol, Boackle Susan A, Brown Elizabeth E, Chang Deh-Ming, Criswell Lindsey A, Edberg Jeffrey C, Freedman Barry I, Gregersen Peter K, Gilkeson Gary S, Jacob Chaim O, James Judith A, Kamen Diane L, Kimberly Robert P, Martin Javier, Merrill Joan T, Niewold Timothy B, Park So-Yeon, Petri Michelle A, Pons-Estel Bernardo A, Ramsey-Goldman Rosalind, Reveille John D, Song Yeong Wook, Stevens Anne M, Tsao Betty P, Vila Luis M, Vyse Timothy J, Yu Chack-Yung, Guthridge Joel M, Bruner Gail R, Langefeld Carl D, Montgomery Courtney, Harley John B, Scofield R Hal, Gaffney Patrick M, Moser Kathy L
Abstract excerpt
Systemic lupus erythematosus (SLE) is considered to be the prototypic autoimmune disease, with a complex genetic architecture influenced by environmental factors. We sought to replicate a putative association at 11p13 not yet exceeding genome-wide significance (p < 5 × 10(-8)) identified in a genome-wide association study (GWAS). Our GWA scan identified two intergenic SNPs located between PDHX and CD44 showing...
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