Article

Unifying comprehensive genomics and transcriptomics in individual cells to illuminate oncogenic and drug resistance mechanisms

2022-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Discovering transcriptional variation in the absence of underlying genomic contributions hinders understanding of molecular mechanisms of disease. To assess this coordination in individual cells, we leveraged a new workflow, ResolveOME, exploiting the attributes of primary template-directed amplification (PTA) to enable accurate, complete-genome assessment of single-nucleotide variation in conju...

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Literature Corpus work: 8d822b6e-1bd3-5509-aeee-8797570cfd15
DOI: 10.1101/2022.04.29.489440

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