Article
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome.
EMBO molecular medicine - 7 Oct 2020
Brueffer Christian, Gladchuk Sergii, Winter Christof, Vallon-Christersson Johan, Hegardt Cecilia, Häkkinen Jari, George Anthony M, Chen Yilun, Ehinger Anna, Larsson Christer, Loman Niklas, Malmberg Martin, Rydén Lisa, Borg Åke, Saal Lao H
Abstract excerpt
Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN-B (ClinicalTrials.gov: NCT02306096), a prospective study elucidating the transcriptomic profiles for thousands of breast cancers, we developed a RNA-seq pipeline for detection of SNVs/indels and profiled a real-world cohort of...
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