Article

Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation

2025-02-08

Abstract excerpt

Enterocytes and four secretory cell types derive from stem cells located in intestinal crypts. Whereas secretory goblet and Paneth cells have long been considered distinct, we find high overlap in their transcripts and sites of accessible chromatin, in marked contrast to those of sibling enteroendocrine or tuft cells. Mouse and human goblet and Paneth cells express extraordinary fractions of selective antimicrobia...

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Literature Corpus work: 26c4d34d-fc38-5482-b52f-c5ec7abbc847
DOI: 10.1101/2025.02.07.636917

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