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Article

Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell.

Cell stem cell - 5 Jun 2025

Bhattacharya Swarnabh, Tie Guodong, Singh Pratik N P, Malagola Ermanno, Eskiocak Onur, He Ruiyang, Kraiczy Judith, Gu Wei, Perlov Yakov, Alici-Garipcan Aybuke, Beyaz Semir, Wang Timothy C, Zhou Qiao, Shivdasani Ramesh A

Abstract excerpt

Enterocytes and four classic secretory cell types derive from intestinal epithelial stem cells. Based on morphology, location, and canonical markers, goblet and Paneth cells are considered distinct secretory types. Here, we report high overlap in their transcripts and sites of accessible chromatin, in marked contrast to those of their enteroendocrine or tuft cell siblings. Mouse and human goblet and Paneth cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40203837
DOI: 10.1016/j.stem.2025.03.005
PMCID: PMC12145258

Genes

ATOH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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