Article

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn’s disease

2020-02-07

Abstract excerpt

<h4>Summary</h4> Human gut development requires the orchestrated interaction of various differentiating cell types. Here we generate an in-depth single-cell map of the developing human intestine at 6–10 weeks post-conception, a period marked by crypt-villus formation. Our analysis reveals the transcriptional profile of cycling epithelial precursor cells, which are distinct from LGR5-expressing cells. We use compu...

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Literature Corpus work: b3ce9ff4-ca8d-597b-9e82-b30558a0ff94
DOI: 10.1101/2020.02.06.937110

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