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Computational Transcriptional Deconvolution and Purity-Corrected Analysis Characterizes Invasion Programs in IDH-Wildtype Glioblastoma: Proneural Distinctiveness, Transcription Factor Proxy Activity, and Dual Mechanisms of Therapeutic Resistance

2026-05-20

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<title>Abstract</title> <p>Background Glioblastoma (GBM) recurrence originates from the non-resectable invasive margin. While the Mesenchymal (ME) subtype has traditionally been considered the most invasive, this assignment is confounded by tumor purity and the simplicity of early gene signatures. We undertook a comprehensive, purity-corrected computational transcriptional deconvolution to systematically charact...

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Literature Corpus work: 8d3dcb67-f792-5711-a242-cb5aba697aec
DOI: 10.21203/rs.3.rs-9716905/v1

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Computational Transcriptional Deconvolution and Purity-Corrected Analysis Characterizes Invasion Programs in IDH-Wildtype Glioblastoma: Proneural Distinctiveness, Transcription Factor Proxy Activity, and Dual Mechanisms of Therapeutic ResistanceDOI 10.21203/rs.3.rs-9716905/v1Read

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