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DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient Survival

2025-03-03

Abstract excerpt

<h4>Background</h4> IDH-wildtype glioblastoma (GBM) is an aggressive, heterogeneous brain tumor with limited treatment options. DNA methylation profiling allows detailed tumor characterization. This study applies methylation-based deconvolution to define GBM’s cellular composition and its association with patient outcomes. <h4>Methods</h4> We generated oligodendroglial precursor cells at various developmental st...

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Literature Corpus work
3c8d3f71-6a7f-50e6-ac80-12463a1e4376
DOI
10.1101/2025.02.27.640603
Open publication

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DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient SurvivalDOI 10.1101/2025.02.27.640603
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