Article

An integrative single-cell and bulk transcriptomic framework prioritizes a glioblastoma stemness program associated with immune suppression and adverse outcome

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>Purpose Clinically useful glioblastoma (GBM)-specific stemness biomarker programs remain incompletely defined. We aimed to prioritize a GBM-focused stemness program and candidate markers by integrating single-cell, single-nucleus, and bulk transcriptomic data. Methods We integrated scRNA-seq data from 55 GBM samples and snRNA-seq data from 10 GBM samples. Malignant-cell stemness was q...

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Literature Corpus work: fa43df3b-c5a3-56e3-84c9-041f0ac36a91
DOI: 10.21203/rs.3.rs-9643632/v1

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