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Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

10 Oct 2024

Abstract excerpt

BACKGROUND: Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of the tumor microenvironment (TME) contribute to overall tumor organization and to programs of invasion may reveal opportunities for improved therapeutic strategies. RESULTS:...

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PMID: 39390467
DOI: 10.1186/s13059-024-03407-3

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