Article

Pathway-based approach reveals differential sensitivity of glioblastoma to E2F1 inhibition

2021-06-19

Abstract excerpt

Targeting glioblastoma (GBM) based on molecular subtyping have not yet translated into successful therapies. Here, we used gene set enrichment analysis (GSEA) to conduct an unsupervised clustering analysis to condense the gene expression data from bulk patient samples and patient-derived gliomasphere lines into new gene lists. We then identified key molecular pathways differentially regulated between tumors. These...

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Literature Corpus work: 6e36af22-80d2-5eb1-a91b-244fffb2caba
DOI: 10.1101/2021.06.19.449118

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