Article

Knockdown of microglial iron import gene, DMT1, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer’s disease

2024-06-27

Abstract excerpt

<title>Abstract</title> <p>Background Microglial cell iron load and inflammatory activation are significant hallmarks of late-stage Alzheimer’s disease (AD). <italic>In vitro</italic>, microglia preferentially upregulate the iron importer, divalent metal transporter 1 (DMT1, gene name <italic>Slc11a2</italic>) in response to inflammatory stimuli, and excess iron can augment cellular inflammation, suggesting a fe...

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Literature Corpus work: 1b9cd790-74ad-5640-8511-865e06483b80
DOI: 10.21203/rs.3.rs-4559940/v1

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