Article

HIV integration in the human brain is linked to microglial activation and 3D genome remodeling

2022-05-04

Abstract excerpt

Exploration of genome organization and function in the HIV infected brain is critical to aid in the development of treatments for HIV-associated neurocognitive disorder (HAND) and HIV cure strategies. Here, we generated a resource comprised of single nuclei transcriptomics, complemented by cell-type-specific Hi-C chromosomal conformation (‘3D genome’) and viral integration site sequencing (IS-seq) in frontal brain...

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Literature Corpus work: 8cf71e9a-b881-5e89-a109-77e6c2815fea
DOI: 10.1101/2022.05.03.490485

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