Article

Early pandemic HIV-1 integration site preferences differ across anatomical reservoirs

2025-03-03

Abstract excerpt

Despite effective viral suppression with modern antiretroviral therapy (ART), HIV-1 persists in latent reservoirs across multiple tissues. Integration into the host genome is essential for viral persistence, yet the characteristics of these reservoir sites across anatomical locations remain poorly understood. To address this, we analyzed integration sites from matched esophagus, PBL/PBMC, stomach, duodenum, colon,...

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Literature Corpus work: 47889f62-d352-5986-9d3b-8558d554a6c0
DOI: 10.1101/2025.03.03.641190

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