Article

Melanoma plasticity is controlled by a TRIM28-JUNB mediated switch

2019-09-20

Abstract excerpt

The introduction of immune checkpoint blockade has revolutionized the treatment of metastatic melanoma 1 . However, 40-60% of patients with metastatic melanoma do not respond to immune checkpoint blockade, and a significant fraction of patients acquire resistance to treatment 2,3 . This resilience and aggressiveness of melanoma tumors is partly due to their ability to switch between invasive and proliferative st...

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Literature Corpus work: 8cd51ea7-3896-5b05-bc65-386dc33cbe23
DOI: 10.1101/777771

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