Article

The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

2025-05-24

Abstract excerpt

Cancer cell plasticity plays a key role in tumor progression and treatment resistance in melanoma. While the transcriptional programs enabling adaptative switching between melanocytic and mesenchymal phenotypes are well characterized, unravelling druggable epigenetic regulators that sustain melanoma cell adaptation and resistance remains crucial. Herein, we identified TRIM24, a bromodomain protein frequently upreg...

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Identifiers and source

Literature Corpus work: fb47b55c-2ca2-5813-81ff-dc6924a171a0
DOI: 10.1101/2025.05.20.654822

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