Article

Integration of exogenous and endogenous co-stimulatory signals by CAR-Tregs

2022-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Regulatory T cells (Tregs) expressing chimeric antigen receptors (CAR) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding CARs. However, these models could underrepresent interactions between CAR-Tregs, antigen-presenting cells (APCs) and donor-specif...

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Literature Corpus work: 8cafd851-a5f8-5afa-8bdf-662d82294f96
DOI: 10.1101/2022.11.10.516049

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