Article

Gene editing of <i>CD3 epsilon</i> gene to redirect regulatory T cells for adoptive T cell transfer

2024-03-18

Abstract excerpt

I. Adoptive transfer of regulatory T cells (Tregs) is a promising strategy to combat immunopathologies in transplantation and autoimmune diseases. Antigen-specific Tregs are more effective in modulating undesired immune reactions, but their low frequency in peripheral blood poses challenges for manufacturing and their clinical application. Chimeric antigen receptors (CARs) have been used to redirect the specificit...

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Literature Corpus work: 3b0f9a46-b88b-5fee-ae90-b877cea46014
DOI: 10.1101/2024.03.18.584896

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