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Challenges and opportunities of allogeneic donor-derived CAR T cells

18 Sept 2015

Abstract excerpt

PURPOSE OF REVIEW: As T cells engineered with chimeric antigen receptors (CARs) are entering advanced phases of clinical trial testing with promising results, the potential implications of use in an allogeneic environment are emerging as an important consideration. This review discusses the use of allogeneic CAR therapy, the potential effects of T-cell receptor (TCR) signaling on CAR T-cell efficacy, and the...

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PMID: 26390167
DOI: 10.1097/moh.0000000000000181

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