Article

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs

2019-08-29

Abstract excerpt

<h4>Summary</h4> Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptor (CARs) are a potent immunosuppressive cellular therapy in multiple disease models. To date the majority of CAR Treg studies employed second generation CARs, encoding a CD28 or 4-1BB co-receptor signaling domain and CD3ζ, but it was not known if this CAR design was optimal for Tregs. Using an HLA-A2-specific CAR...

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Literature Corpus work: eb4982a1-7fb9-5f37-8cf7-243172b42a18
DOI: 10.1101/749721

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