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Article

Overcoming barriers to widespread use of CAR-Treg therapy in organ transplant recipients.

HLA - 1 Jun 2022

Cremoni Marion, Massa Filippo, Sicard Antoine

Abstract excerpt

Preventing allograft rejection has been the main challenge of transplantation medicine since the discovery of immune responses against foreign HLA molecules in the mid-20th century. Prevention of rejection currently relies on immunosuppressive drugs, which lack antigen specificity and therefore increase the risk for infections and cancers. Adoptive cell therapy with donor-reactive regulatory T cells (Tregs) has...

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PMID: 35233971
DOI: 10.1111/tan.14591

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