Article
The consensus molecular subtypes of colorectal cancer.
Nature medicine - 1 Nov 2015
Guinney Justin, Dienstmann Rodrigo, Wang Xin, de Reyniès Aurélien, Schlicker Andreas, Soneson Charlotte, Marisa Laetitia, Roepman Paul, Nyamundanda Gift, Angelino Paolo, Bot Brian M, Morris Jeffrey S, Simon Iris M, Gerster Sarah, Fessler Evelyn, De Sousa E Melo Felipe, Missiaglia Edoardo, Ramay Hena, Barras David, Homicsko Krisztian, Maru Dipen, Manyam Ganiraju C, Broom Bradley, Boige Valerie, Perez-Villamil Beatriz, Laderas Ted, Salazar Ramon, Gray Joe W, Hanahan Douglas, Tabernero Josep, Bernards Rene, Friend Stephen H, Laurent-Puig Pierre, Medema Jan Paul, Sadanandam Anguraj, Wessels Lodewyk, Delorenzi Mauro, Kopetz Scott, Vermeulen Louis, Tejpar Sabine
Abstract excerpt
Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification...
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