Article

A Single-Cell Atlas Reveals Cancer Cell Plasticity and Stromal-Immune Remodeling in Uterine Carcinosarcoma Across Diverse Ancestries

2026-04-24

Abstract excerpt

Uterine carcinosarcoma (UCS) is an aggressive endometrial cancer defined by coexisting malignant epithelial and mesenchymal components, rapid metastatic dissemination, and poor therapeutic response. However, its cellular ecosystem remains poorly resolved, particularly in patients of African ancestry who are underrepresented in genomic datasets despite a disproportionate disease burden. Here, we generated a single-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 030dcdf2-1352-569b-9546-e42507297e6d
DOI: 10.64898/2026.04.21.720013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Single-Cell Atlas Reveals Cancer Cell Plasticity and Stromal-Immune Remodeling in Uterine Carcinosarcoma Across Diverse AncestriesDOI 10.64898/2026.04.21.720013Read

A High-Fidelity and Ancestrally Inclusive Patient-Derived Organoid Platform Resolves Cancer Cell Plasticity in Uterine CarcinosarcomaSemantic proximity Read

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.Semantic proximity Read

Dynamic uterine microenvironment drives endometrial adenocarcinoma carcinogenesis and progressionSemantic proximity Read

A Pan-cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell ProfilingSemantic proximity Read

Multidimensional Single-Cell Transcriptomic Profiling of Uterine Leiomyosarcomas Reveals Distinct Tumor States with Inferred Therapeutic VulnerabilitiesSemantic proximity Read

Integrated Molecular Characterization of Uterine Carcinosarcoma.Semantic proximity Read

Spatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal MetastasisSemantic proximity Read

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancersSemantic proximity Read

Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.Semantic proximity Read

Single-Cell Transcriptomics Reveals Tissue Architecture in Ovarian CarcinosarcomaSemantic proximity Read

Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinomaSemantic proximity Read

Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancerSemantic proximity Read