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Spatial and single‐cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancer

1 Mar 2025

Abstract excerpt

Colorectal cancer (CRC) exhibits a complex tumor microenvironment with significant cellular heterogeneity, particularly involving cancer-associated fibroblasts that influence tumor behavior and metastasis. This study integrated single-cell RNA sequencing and spatial transcriptomics to dissect fibroblast heterogeneity in CRC. Data processing employed Seurat for quality control, principal component analysis for...

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PMID: 40068177
DOI: 10.1002/biof.70012

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