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Article

An epithelial cell fate-driven predictive model for liver metastasis risk in primary colorectal cancer through single-cell and multi-omics integration.

Journal of translational medicine - 8 Jun 2026

Yin Min, Bo Xiaochen, Li Yaoyao, Yu Simin, Lin Zhijie, Wang Mei, Wu Jian, Zhou Ming, Kong Lingmin, Zhu Yefei, Xiao Weiming, Ding Yanbing

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is the third most prevalent form of cancer worldwide, with colorectal cancer liver metastases (CRLM) representing a principal cause of CRC-related mortality. However, a lack of molecular subgroups based on the differentiation states of diverse cell types in CRLM poses a significant barrier to progress in precision therapy. METHODS: We integrated single-cell RNA sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42260568
DOI: 10.1186/s12967-026-08375-9
PMCID: PMC13474844

Genes

HSPA1A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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