Article

Blood-borne sphingosine 1-phosphate maintains vascular resistance and cardiac function

2025-01-19

Abstract excerpt

G protein-coupled receptors (GPCRs) are key regulators of cardiovascular function that provide targets for the treatment of cardiovascular disease. Sphingosine 1-phosphate (S1P) is an erythrocyte- and platelet-derived lipid mediator with cognate GPCRs on endothelial cells (EC), vascular smooth muscle cells (VSMC) and cardiomyocytes. S1P circulates in plasma bound to apolipoprotein M (ApoM)-containing high-density...

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Literature Corpus work: 8c9a8528-ad78-518f-9546-ecda5b078cb4
DOI: 10.1101/2025.01.15.633211

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