Article

A novel mouse model of hypertensive emergency with multiorgan microvascular disease implicating the VEGFA/sFlt-1 balance

2026-03-06

Abstract excerpt

<h4>Background</h4> Hypertensive emergency (HTEM) is defined by abrupt blood pressure elevation with acute multi-organ damage, yet the mechanisms predisposing only a subset of hypertensive individuals to HTEM remain unclear. Progress has been limited by the lack of a mouse model that faithfully replicates human disease. We aimed to identify determinants of susceptibility to hypertensive microvascular injury and c...

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Literature Corpus work: 74d58b34-2810-5b55-bf14-544f2fd854c2
DOI: 10.64898/2026.03.03.709451

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