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Article

HDLs in crises

19 Apr 2016

Abstract excerpt

PURPOSE OF REVIEW: The clinical utility of HDLs has been scrutinized upon the publication of Mendelian randomization studies showing no effect of HDL-cholesterol (HDL-C) modifying variants on cardiovascular disease (CVD) outcome. The failures of randomized controlled HDL-C-directed intervention trials have further fueled this skepticism. This general criticism originates from oversimplification that has equated...

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PMID: 27031272
DOI: 10.1097/mol.0000000000000294

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