Article

Differential S1PR Expression and Altered Barrier, and Inflammatory Marker Levels in Human Brain Endothelial Cells Following Acute Ischemia-Reperfusion Like Injury

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> There are five known sphingosine-1-phosphate receptor (S1PR) types, and each type is coupled to diverse heterotrimeric G-protein subunits. S1PR type 1 (S1PR1) is highly expressed in the endothelium and receptor signaling pathways beneficially impact barrier function, thus there is a growing interest in the potential therapeutic role of S1PR1 during acute stroke injury. However, assessment of cer...

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Literature Corpus work: cfc76f74-1875-531e-b883-a18d4f268121
DOI: 10.1101/2025.10.23.684217

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