Article

Soffritto: a deep-learning model for predicting high-resolution replication timing

2025-01-26

Abstract excerpt

<h4>Motivation</h4> Replication Timing (RT) refers to the order by which DNA loci are replicated during S phase. RT is cell-type specific and implicated in cellular processes including transcription, differentiation, and disease. RT is typically quantified genome-wide using two-fraction assays (e.g., Repli-Seq) which sort cells into early and late S phase fractions followed by DNA sequencing yielding a ratio as t...

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Literature Corpus work: 76cec8cf-eeac-5468-9508-05a8f787dd3d
DOI: 10.1101/2025.01.23.634644

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