Article

Personalized Morphology, Replication Timing, and RNA based Gene Expression Networks for Basal-like and Classical subtyping genes in Pancreatic Adenocarcinoma

2026-03-16

Abstract excerpt

Network biology traditionally identifies gene correlations that reflect biological pathways. While LIONESS enables individualized gene networks, the influence of replication timing on these correlations remains unexplored. Replication timing reflects the temporal order of DNA synthesis and is tightly linked to chromatin state, methylation, and transcriptional stability, all of which affect tumor behavior. Integrat...

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Literature Corpus work: cb4dd08d-167b-5583-aea5-1f5a8e3e956f
DOI: 10.64898/2026.03.12.711434

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