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Article

A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.

Science (New York, N.Y.) - 9 Dec 2005

Bhalla Needhi, Dernburg Abby F

Abstract excerpt

We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in...

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Identifiers

PMID: 16339446
DOI: 10.1126/science.1117468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.PMID 16339446Read ↗

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