Article

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma

2022-05-14

Abstract excerpt

Malignant melanoma is one of the most common types of cancer in the United States. Despite recent and well-described progress in melanoma treatment, advanced disease still carries a poor prognosis for many patients and chemotherapy has been appropriately abandoned as a front-line option. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency in cancer. The enzyme is pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 270d01c7-230a-5950-9302-921434eaaf00
DOI: 10.1101/2022.05.13.491880

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Wild-type IDH1 inhibition enhances chemotherapy response in melanomaDOI 10.1101/2022.05.13.491880Read

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.Semantic proximity Read

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitationSemantic proximity Read

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancerSemantic proximity Read

Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous OncologySemantic proximity Read

Recent advances of IDH1 mutant inhibitor in cancer therapySemantic proximity Read

Mutant IDH1 confers an in vivo growth in a melanoma cell line with BRAF mutation.Semantic proximity Read

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.Semantic proximity Read

Clinical and translational study of ivosidenib plus nivolumab in advanced solid tumors harboring IDH1 mutationsSemantic proximity Read

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.Semantic proximity Read

The roles of IDH1 in tumor metabolism and immunity.Semantic proximity Read

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.Semantic proximity Read

Isocitrate dehydrogenase 1 mutations in melanoma frequently co-occur with NRAS mutations.Semantic proximity Read