Article

Parkinson’s disease‒associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy

2020-12-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold>Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including <italic>PINK1</italic> and <italic>PARK2</italic>, are directly involved in processes such as mitophagy that maintain mitochondrial health. The dominant p.D620N variant in <italic>VPS35</italic> has also been associa...

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Literature Corpus work: 8c776b7e-d85a-54e9-af15-efa80586ca6b
DOI: 10.21203/rs.3.rs-131693/v1

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