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Article

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2021

Hanss Zoé, Larsen Simone B, Antony Paul, Mencke Pauline, Massart François, Jarazo Javier, Schwamborn Jens C, Barbuti Peter A, Mellick George D, Krüger Rejko

Abstract excerpt

BACKGROUND: VPS35 is part of the retromer complex and is responsible for the trafficking and recycling of proteins implicated in autophagy and lysosomal degradation, but also takes part in the degradation of mitochondrial proteins via mitochondria-derived vesicles. The p.D620N mutation of VPS35 causes an autosomal-dominant form of Parkinson's disease (PD), clinically representing typical PD. OBJECTIVE: Most of...

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Identifiers

PMID: 33142012
DOI: 10.1002/mds.28365
PMCID: PMC8048506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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